We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The complete genome sequence of the gastric pathogen Helicobacter pylori.
- Authors
Tomb, J F; White, O; Kerlavage, A R; Clayton, R A; Sutton, G G; Fleischmann, R D; Ketchum, K A; Klenk, H P; Gill, S; Dougherty, B A; Nelson, K; Quackenbush, J; Zhou, L; Kirkness, E F; Peterson, S; Loftus, B; Richardson, D; Dodson, R; Khalak, H G; Glodek, A; McKenney, K; Fitzegerald, L M; Lee, N; Adams, M D; Hickey, E K; Berg, D E; Gocayne, J D; Utterback, T R; Peterson, J D; Kelley, J M; Cotton, M D; Weidman, J M; Fujii, C; Bowman, C; Watthey, L; Wallin, E; Hayes, W S; Borodovsky, M; Karp, P D; Smith, H O; Fraser, C M; Venter, J C
- Abstract
Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.
- Publication
Nature, 1997, Vol 388, Issue 6642, p539
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/41483