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- Title
X-linked IAP is a direct inhibitor of cell-death proteases.
- Authors
Deveraux, Q L; Takahashi, R; Salvesen, G S; Reed, J C
- Abstract
The inhibitor-of-apoptosis (IAP) family of genes has an evolutionarily conserved role in regulating programmed cell death in animals ranging from insects to humans. Ectopic expression of human IAP proteins can suppress cell death induced by a variety of stimuli, but the mechanism of this inhibition was previously unknown. Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. As the caspases are highly conserved throughout the animal kingdom and are the principal effectors of apoptosis, our findings suggest how IAPs might inhibit cell death, providing evidence for a mechanism of action for these mammalian cell-death suppressors.
- Publication
Nature, 1997, Vol 388, Issue 6639, p300
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/40901