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Title
A structural basis for mutational inactivation of the tumour suppressor Smad4.
Authors
Yigong Shi; Hata, Akiko
Abstract
Describes the crystal structure of the C-terminal domain (CTD) of the Smad4/DPC4 tumour suppressor, determined at 2.5 angstroms resolution. What the structure reveals; Link between the structure and the majority of tumour-derived missense mutations; Impact of the mutations; The inactivation of Smad4/DPC4 in a variety of cancers.