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- Title
Reprogramming of genome function through epigenetic inheritance.
- Authors
Surani, M A
- Abstract
Most cells contain the same set of genes and yet they are extremely diverse in appearance and functions. It is the selective expression and repression of genes that determines the specific properties of individual cells. Nevertheless, even when fully differentiated, any cell can potentially be reprogrammed back to totipotency, which in turn results in re-differentiation of the full repertoire of adult cells from a single original cell of any kind. Mechanisms that regulate this exceptional genomic plasticity and the state of totipotency are being unravelled, and will enhance our ability to manipulate stem cells for therapeutic purposes.
- Publication
Nature, 2001, Vol 414, Issue 6859, p122
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/35102186