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- Title
Stem cells, cancer, and cancer stem cells.
- Authors
Reya, T; Morrison, S J; Clarke, M F; Weissman, I L
- Abstract
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells' - rare cells with indefinite potential for self-renewal that drive tumorigenesis.
- Publication
Nature, 2001, Vol 414, Issue 6859, p105
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/35102167