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- Title
Commuting the death sentence: how oocytes strive to survive.
- Authors
Tilly, J L
- Abstract
Programmed cell death claims up to 99.9% of the cells in the mammalian female germ line, which eventually drives irreversible infertility and ovarian failure - the menopause in humans. New insights into the mechanisms that underlie germ-cell apoptosis have been provided by the study of oocyte death in lower organisms and in genetically manipulated mice that lack apoptosis-regulatory proteins. With new therapeutic tools to control fertility, oocyte quality and ovarian lifespan on the horizon, understanding how and why the female body creates, only to delete, so many germ cells is imperative.
- Publication
Nature reviews. Molecular cell biology, 2001, Vol 2, Issue 11, p838
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/35099086