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- Title
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly.
- Authors
Ming-Juan Luo; Zhaolan Zhou; Magni, Keith; Christoforides, Claudine; Rappsilber, Juri; Mann, Matthias; Reed, Robin
- Abstract
Shows that the conserved DEAD-box helicase UAP56, which functions during spliceosome assembly, interacts directly and highly specifically with Aly. Injection of GST-UAP56 into Xenopus oocytes and fushi tarazu pre-messenger RNA and control RNAs; Protein interaction in mammalian cells; Evidence that excess UAP56 inhibits the recruitment of Aly to the spliced mRNA.
- Publication
Nature, 2001, Vol 413, Issue 6856, p644
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/35098106