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- Title
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury.
- Authors
Panikashvili, D; Simeonidou, C; Ben-Shabat, S; Hanus, L; Breuer, A; Mechoulam, R; Shohami, E
- Abstract
Traumatic brain injury triggers the accumulation of harmful mediators that may lead to secondary damage. Protective mechanisms to attenuate damage are also set in motion. 2-Arachidonoyl glycerol (2-AG) is an endogenous cannabinoid, identified both in the periphery and in the brain, but its physiological roles have been only partially clarified. Here we show that, after injury to the mouse brain, 2-AG may have a neuroprotective role in which the cannabinoid system is involved. After closed head injury (CHI) in mice, the level of endogenous 2-AG was significantly elevated. We administered synthetic 2-AG to mice after CHI and found significant reduction of brain oedema, better clinical recovery, reduced infarct volume and reduced hippocampal cell death compared with controls. When 2-AG was administered together with additional inactive 2-acyl-glycerols that are normally present in the brain, functional recovery was significantly enhanced. The beneficial effect of 2-AG was dose-dependently attenuated by SR-141761A, an antagonist of the CB1 cannabinoid receptor.
- Publication
Nature, 2001, Vol 413, Issue 6855, p527
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/35097089