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- Title
A decade of CDK5.
- Authors
Dhavan, R; Tsai, L H
- Abstract
Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction. Recent evidence indicates that deregulation of this kinase is involved in the pathology of neurodegenerative diseases.
- Publication
Nature reviews. Molecular cell biology, 2001, Vol 2, Issue 10, p749
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/35096019