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- Title
The development of androgen-independent prostate cancer.
- Authors
Feldman, B J; Feldman, D
- Abstract
The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress. Cancers that are not cured by surgery eventually become androgen independent, rendering anti-androgen therapy ineffective. But how does androgen independence arise? We predict that understanding the pathways that lead to the development of androgen-independent prostate cancer will pave the way to effective therapies for these, at present, untreatable cancers.
- Publication
Nature reviews. Cancer, 2001, Vol 1, Issue 1, p34
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/35094009