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- Title
MOUSE GENOMIC TECHNOLOGIES: ENGINEERING CHROMOSOMAL REARRANGEMENTS IN MICE.
- Authors
Yu, Yuejin; Bradley, Allan
- Abstract
The combination of gene-targeting techniques in mouse embryonic stem cells and the Cre/loxP site-specific recombination system has resulted in the emergence of chromosomal-engineering technology in mice. This advance has opened up new opportunities for modelling human diseases that are associated with chromosomal rearrangements. It has also led to the generation of visibly marked deletions and balancer chromosomes in mice, which provide essential reagents for maximizing the efficiency of large-scale mutagenesis efforts and which will accelerate the functional annotation of mammalian genomes, including the human genome.
- Publication
Nature Reviews Genetics, 2001, Vol 2, Issue 10, p780
- ISSN
1471-0056
- Publication type
Academic Journal
- DOI
10.1038/35093564