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- Title
Molecular mechanisms of nociception.
- Authors
Julius, D; Basbaum, A I
- Abstract
The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating. This transition to a chronic phase involves changes within the spinal cord and brain, but there is also remarkable modulation where pain messages are initiated - at the level of the primary sensory neuron. Efforts to determine how these neurons detect pain-producing stimuli of a thermal, mechanical or chemical nature have revealed new signalling mechanisms and brought us closer to understanding the molecular events that facilitate transitions from acute to persistent pain.
- Publication
Nature, 2001, Vol 413, Issue 6852, p203
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/35093019