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- Title
TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
- Authors
Perlman, R; Schiemann, W P; Brooks, M W; Lodish, H F; Weinberg, R A
- Abstract
Transforming growth factor-beta (TGF-beta) is a multifunctional growth factor that has a principal role in growth control through both its cytostatic effect on many different epithelial cell types and its ability to induce programmed cell death in a variety of other cell types. Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and programmed cell death induced by Fas. The carboxy-terminal portion of Daxx functions as a dominant-negative inhibitor of TGF-beta-induced apoptosis in B-cell lymphomas, and antisense oligonucleotides to Daxx inhibit TGF-beta-induced apoptosis in mouse hepatocytes. Furthermore, Daxx is involved in mediating JNK activation by TGF-beta. Our findings associate Daxx directly with the TGF-beta apoptotic-signalling pathway, and make a biochemical connection between the receptors for TGF-beta and the apoptotic machinery.
- Publication
Nature cell biology, 2001, Vol 3, Issue 8, p708
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/35087019