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Title
Transcriptional regulation by the phosphorylation-dependent factor CREB.
Authors
Mayr, B; Montminy, M
Abstract
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?