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- Title
The microenvironment of the tumour-host interface.
- Authors
Liotta, L A; Kohn, E C
- Abstract
Throughout the entire process of cancer aetiology, progression and metastasis, the microenvironment of the local host tissue can be an active participant. Invasion occurs within a tumour-host microecology, where stroma and tumour cells exchange enzymes and cytokines that modify the local extracellular matrix, stimulate migration, and promote proliferation and survival. A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development.
- Publication
Nature, 2001, Vol 411, Issue 6835, p375
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/35077241