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- Title
Cellular immune responses to HIV.
- Authors
McMichael, A J; Rowland-Jones, S L
- Abstract
The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4+ T cells and the uninfected CD8+ T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.
- Publication
Nature, 2001, Vol 410, Issue 6831, p980
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/35073658