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- Title
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans.
- Authors
Limin Liu; Hausladen, Alfred; Ming Zeng; Que, Loretta; Heitman, Joseph; Stamler, Jonathan S.
- Abstract
Reports on the purification of a single activity from Escherichia coli, Saccharomyces cerevisiae and mouse macrophages that metabolizes S-nitrosoglutathione (GSNO), and shows that it is the glutathione-dependent formaldehyde dehydrogenase. Finding of GSNO reluctase activity that is widely distributed in mammals; Conclusion that GSNO reductase is evolutionarily conserved from bacteria to humans, is critical for S-nitrosoid (SNO) homeostasis, and protects against nitrosative stress.
- Publication
Nature, 2001, Vol 410, Issue 6827, p490
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/35068596