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- Title
Multifunctional strands in tight junctions.
- Authors
Tsukita, S; Furuse, M; Itoh, M
- Abstract
Tight junctions are one mode of cell-cell adhesion in epithelial and endothelial cellular sheets. They act as a primary barrier to the diffusion of solutes through the intercellular space, create a boundary between the apical and the basolateral plasma membrane domains, and recruit various cytoskeletal as well as signalling molecules at their cytoplasmic surface. New insights into the molecular architecture of tight junctions allow us to now discuss the structure and functions of this unique cell-cell adhesion apparatus in molecular terms.
- Publication
Nature reviews. Molecular cell biology, 2001, Vol 2, Issue 4, p285
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/35067088