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- Title
Aberrant CFTR-dependent HCO[sub3] transport in mutations associated with cystic fibrosis.
- Authors
Joo Young Choi; Muallem, Daniella; Kiselyov, Kirill; Min Goo Lee; Thomas, Philip J.; Muallem, Shmuel
- Abstract
Examines Cl-coupled HCO[sub3] transport by cystic fibrosis transmembrane conductance regulator (CFTR) mutants that retain substantial or normal Cl channel activity. Findings showing that mutants reported to be associated with cystic fibrosis (CF) with pancreatic insufficiency do not support HCO[sub3] transport, and those associated with pancreatic sufficiency show reduced HCO[sub3] transport; Importance of HCO[sub3] transport in the function of secretory epithelia and in CF.
- Publication
Nature, 2001, Vol 410, Issue 6824, p94
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/35065099