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Title
Crystal structure of the transcription activator BmrR bound to DNA and a drug.
Authors
Heldwin, Ekaterina E. Zheleznova; Brennan, Richard G.
Abstract
Reports on the structure of multidrug transporter in Bacillus subtilis in complex with the drug tetraphenylphosphonium and a 22-base-pair oligodeoxynucleotide encompassing the promoter. The efflux chemically diverse drugs by multidrug transporters, which is one mechanism of multidrug resistance in bacteria; How the structure reveals an unexpected mechanism for transcription activation.