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- Title
ICOS co-stimulatory receptor is essential for T-cell activation and function.
- Authors
Chen Dong; Juedes, Amy E.; Temann, Ulla-Angela; Shresta, Sujan; Allison, James P.; Ruddle, Nancy H.; Flavell, Richard A.
- Abstract
Shows that T-cell activation and proliferation are defective in the absence of inducible co-stimulatory molecule (ICOS). Generation and analysis of ICOS-deficient mice to understand the role of ICOS in T-cell activation; Failure of cells to produce interleukin-4 when differentiated in vitro or when primed in vivo; Indication that ICOS has a protective role in inflammatory autoimmune diseases.
- Publication
Nature, 2001, Vol 409, Issue 6816, p97
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/35051100