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- Title
The origins, patterns and implications of human spontaneous mutation.
- Authors
Crow, J F
- Abstract
The germline mutation rate in human males, especially older males, is generally much higher than in females, mainly because in males there are many more germ-cell divisions. However, there are some exceptions and many variations. Base substitutions, insertion-deletions, repeat expansions and chromosomal changes each follow different rules. Evidence from evolutionary sequence data indicates that the overall rate of deleterious mutation may be high enough to have a large effect on human well-being. But there are ways in which the impact of deleterious mutations can be mitigated.
- Publication
Nature reviews. Genetics, 2000, Vol 1, Issue 1, p40
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/35049558