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- Title
DNA methylation in health and disease.
- Authors
Robertson, K D; Wolffe, A P
- Abstract
DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These diseases result from the misregulation of genes that occurs with the loss of appropriate epigenetic controls during neuronal development. Recent advances have connected DNA methylation to chromatin-remodelling enzymes, and understanding this link will be central to the design of new therapeutic tools.
- Publication
Nature reviews. Genetics, 2000, Vol 1, Issue 1, p11
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/35049533