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- Title
Rewiring the keyboard: evolvability of the genetic code.
- Authors
Knight, R D; Freeland, S J; Landweber, L F
- Abstract
The genetic code evolved in two distinct phases. First, the 'canonical' code emerged before the last universal ancestor; subsequently, this code diverged in numerous nuclear and organelle lineages. Here, we examine the distribution and causes of these secondary deviations from the canonical genetic code. The majority of non-standard codes arise from alterations in the tRNA, with most occurring by post-transcriptional modifications, such as base modification or RNA editing, rather than by substitutions within tRNA anticodons.
- Publication
Nature reviews. Genetics, 2001, Vol 2, Issue 1, p49
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/35047500