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- Title
α<sub>v</sub>β<sub>5</sub> integrin recruits the CrkII?Dock180?Rac1 complex for phagocytosis of apoptotic cells.
- Authors
Albert, Matthew L.; Kim, Jong-Ii; Birge, Raymond B.
- Abstract
Integrin receptors are important for the phagocytosis of apoptotic cells. However, little is known about their function in mediating internalization, as previous studies used blocking antibodies for the inhibition of binding. Here we show that the α[sub v]β[sub v] receptor mediates both binding and internalization of apoptotic cells. Internalization is dependent upon signalling through the β[sub 5] cytoplasmic tail, and engagement of the α[sub v]β[sub 5] heterodimer results in recruitment of the p130[sup cas]-CrklI-Dock180 molecular complex, which in turn triggers Racl activation and phagosome formation. In addition to defining integrin-receptor signalling as critical for the internalization of apoptotic material, our results also constitute the first evidence in human cells that the CED-2-CED-5-CED-10 complex defined in Caenorhabditis elegans is functionally analagous to the CrklI-Dock180-Rac1 molecular complex in mammalian cells. By linking the α[sub v]β[sub 5] receptor to this molecular switch, we reveal an evolutionarily conserved signalling pathway that is responsible for the recognition and internalization of apoptotic cells by both professional and non-professional phagocytes.
- Publication
Nature Cell Biology, 2000, Vol 2, Issue 12, p899
- ISSN
1465-7392
- Publication type
Academic Journal
- DOI
10.1038/35046549