Your institution may have access to this item. Find your institution then sign in to continue.
Title
The DNA damage response: putting checkpoints in perspective.
Authors
Zhou, B B; Elledge, S J
Abstract
The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.