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- Title
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
- Authors
Hinuma, S; Shintani, Y; Fukusumi, S; Iijima, N; Matsumoto, Y; Hosoya, M; Fujii, R; Watanabe, T; Kikuchi, K; Terao, Y; Yano, T; Yamamoto, T; Kawamata, Y; Habata, Y; Asada, M; Kitada, C; Kurokawa, T; Onda, H; Nishimura, O; Tanaka, M; Ibata, Y; Fujino, M
- Abstract
Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and OT7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases prolactin secretion in rats. Our results indicate that a variety of RFamide-related peptides may exist and function in mammals.
- Publication
Nature cell biology, 2000, Vol 2, Issue 10, p703
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/35036326