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- Title
Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
- Authors
Jijie Chai; Chunying Du; Jia-Wei Wu; Saw Kyin; Xiaodong Wang; Yigong Shi
- Abstract
Presents a study which shows that the mitochondrial protein Smac/DIABLO performs a critical function on apoptosis, or programmed cell death. How Smac/DIABLO promotes the enzymatic activity of mature caspase-3 in addition to the activation of procapsase-3; Importance of the interaction between Smac/DIABLO and apoptosis protein inhibitors; Structure of Smac/DIABLO; Role of the amino-terminal amino acids of Smac/DIABLO.
- Publication
Nature, 2000, Vol 406, Issue 6798, p855
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/35022514