We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Toll-like receptors in the induction of the innate immune response.
- Authors
Aderem, A; Ulevitch, R J
- Abstract
The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.
- Publication
Nature, 2000, Vol 406, Issue 6797, p782
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/35021228