We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
State-dependent cross-inhibition between transmitter-gated cation channels.
- Authors
Khakh, B S; Zhou, X; Sydes, J; Galligan, J J; Lester, H A
- Abstract
Transmitter-gated cation channels are detectors of excitatory chemical signals at synapses in the nervous system. Here we show that structurally distinct alpha3beta4 nicotinic and P2X2 channels influence each other when co-activated. The activation of one channel type affects distinct kinetic and conductance states of the other, and co-activation results in non-additive responses owing to inhibition of both channel types. State-dependent inhibition of nicotinic channels is revealed most clearly with mutant P2X2 channels, and inhibition is decreased at lower densities of channel expression. In synaptically coupled myenteric neurons, nicotinic fast excitatory postsynaptic currents are occluded during activation of endogenously co-expressed P2X channels. Our data provide a molecular basis and a synaptic context for cross-inhibition between transmitter-gated channels.
- Publication
Nature, 2000, Vol 406, Issue 6794, p405
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/35019066