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- Title
Searching for genetic determinants in the new millennium.
- Authors
Risch, N J
- Abstract
Human genetics is now at a critical juncture. The molecular methods used successfully to identify the genes underlying rare mendelian syndromes are failing to find the numerous genes causing more common, familial, non-mendelian diseases. With the human genome sequence nearing completion, new opportunities are being presented for unravelling the complex genetic basis of non-mendelian disorders based on large-scale genome-wide studies. Considerable debate has arisen regarding the best approach to take. In this review I discuss these issues, together with suggestions for optimal post-genome strategies.
- Publication
Nature, 2000, Vol 405, Issue 6788, p847
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/35015718