We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
- Authors
Li, X; Pontén, A; Aase, K; Karlsson, L; Abramsson, A; Uutela, M; Bäckström, G; Hellström, M; Boström, H; Li, H; Soriano, P; Betsholtz, C; Heldin, C H; Alitalo, K; Ostman, A; Eriksson, U
- Abstract
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.
- Publication
Nature cell biology, 2000, Vol 2, Issue 5, p302
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/35010579