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Title
XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis.
Authors
Malorano, Domenico; Moreau, Jacques
Abstract
Presents evidence that the protein XCDT1 is required for chromosomal DNA replication. Identification of XCDT1 in pre-replication complexes in maternally expressed genes in Xenopus; Similarity for XCDT1 to the fission yeast cdt1; Association of the protein with pre-replicative chromatin; Removal of the protein from chromatin at the onset of DNA synthesis.