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- Title
Dendritic cells and the control of immunity.
- Authors
Banchereau, J; Steinman, R M
- Abstract
B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also tolerize T cells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the immune system.
- Publication
Nature, 1998, Vol 392, Issue 6673, p245
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/32588