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- Title
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
- Authors
McLatchie, L M; Fraser, N J; Main, M J; Wise, A; Brown, J; Thompson, N; Solari, R; Lee, M G; Foord, S M
- Abstract
Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.
- Publication
Nature, 1998, Vol 393, Issue 6683, p333
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/30666