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- Title
Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning.
- Authors
Impey, S; Smith, D M; Obrietan, K; Donahue, R; Wade, C; Storm, D R
- Abstract
Recent studies suggest that the CREB-CRE transcriptional pathway is pivotal in the formation of some types of long-term memory. However, it has not been demonstrated that stimuli that induce learning and memory activate CRE-mediated gene expression. To address this issue, we used a mouse strain transgenic for a CRE-lac Z reporter to examine the effects of hippocampus-dependent learning on CRE-mediated gene expression in the brain. Training for contextual conditioning or passive avoidance led to significant increases in CRE-dependent gene expression in areas CA1 and CA3 of the hippocampus. Auditory cue fear-conditioning, which is amygdala dependent, was associated with increased CRE-mediated gene expression in the amygdala, but not the hippocampus. These data demonstrate that learning in response to behavioral conditioning activates the CRE transcriptional pathway in specific areas of brain.
- Publication
Nature neuroscience, 1998, Vol 1, Issue 7, p595
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/2830