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- Title
Evidence for an unfolding and refolding pathway in cytochrome c.
- Authors
Xu, Y; Mayne, L; Englander, S W
- Abstract
It has been suggested that three partially unfolded forms detected in a native state hydrogen exchange study of oxidized cytochrome c may represent sequential intermediates in an unfolding-refolding pathway. To better define the structure of each intermediate a 'stability labeling' method was used in which the stability of a given segment against unfolding was changed. The condition--folded or unfolded--of the stability-labeled segment in each intermediate could then be determined. The structures found are discrete and native-like and are just those necessary for a sequential pathway.
- Publication
Nature structural biology, 1998, Vol 5, Issue 9, p774
- ISSN
1072-8368
- Publication type
Journal Article
- DOI
10.1038/1810