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- Title
The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat.
- Authors
Ko, S; Deiwick, A; Jäger, M D; Dinkel, A; Rohde, F; Fischer, R; Tsui, T Y; Rittmann, K L; Wonigeit, K; Schlitt, H J
- Abstract
With an organ transplant, hematopoietic donor cells are transferred to the recipient. To study the relevance of the resulting microchimerism for allograft acceptance, we analyzed a rat model of cyclosporine-induced tolerance for strongly incompatible heart allografts. Using a monoclonal antibody that detects a donor-specific CD45 allotype (RT7a), we selectively depleted donor leukocytes at different times after transplantation (days 0 or 18). Depletion was similarly effective at both times. However, only depletion on day 0 prevented tolerance induction and was associated with severe acute or chronic graft rejection. This indicates that passenger leukocytes have an essential immunomodulatory effect on the induction phase of allograft acceptance.
- Publication
Nature medicine, 1999, Vol 5, Issue 11, p1292
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/15248