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- Title
Seminal vesicle production and secretion of growth hormone into seminal fluid.
- Authors
Dyck, M K; Gagné, D; Ouellet, M; Sénéchal, J F; Bélanger, E; Lacroix, D; Sirard, M A; Pothier, F
- Abstract
Production of foreign proteins in the tissues of transgenic animals represents an efficient and economical method of producing therapeutic and pharmaceutical proteins. In this study, we demonstrate that the mouse P12 gene promoter specific to the male accessory sex gland can be used to generate transgenic mice that express human growth hormone (hGH) in their seminal vesicle epithelium. The hGH is secreted into the ejaculated seminal fluids with the seminal vesicle lumen contents containing concentrations of up to 0.5 mg/ml. As semen is a body fluid that can be collected easily on a continuous basis, the production of transgenic animals expressing pharmaceutical proteins into their seminal fluid could prove to be a viable alternative to use of the mammary gland as a bioreactor.
- Publication
Nature biotechnology, 1999, Vol 17, Issue 11, p1087
- ISSN
1087-0156
- Publication type
Journal Article
- DOI
10.1038/15067