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- Title
Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.
- Authors
Persons, D A; Paulson, R F; Loyd, M R; Herley, M T; Bodner, S M; Bernstein, A; Correll, P H; Ney, P A
- Abstract
The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2ss) erythroid cells, was not expressed in Fv2 resistant (Fv2rr) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.
- Publication
Nature genetics, 1999, Vol 23, Issue 2, p159
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/13787