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- Title
Cyclic mechanical strain regulates the development of engineered smooth muscle tissue.
- Authors
Kim, B S; Nikolovski, J; Bonadio, J; Mooney, D J
- Abstract
We show that the appropriate combinations of mechanical stimuli and polymeric scaffolds can enhance the mechanical properties of engineered tissues. The mechanical properties of tissues engineered from cells and polymer scaffolds are significantly lower than the native tissues they replace. We hypothesized that application of mechanical stimuli to engineered tissues would alter their mechanical properties. Smooth muscle tissue was engineered on two different polymeric scaffolds and subjected to cyclic mechanical strain. Short-term application of strain increased proliferation of smooth muscle cells (SMCs) and expression of collagen and elastin, but only when SMCs were adherent to specific scaffolds. Long-term application of cyclic strain upregulated elastin and collagen gene expression and led to increased organization in tissues. This resulted in more than an order of magnitude increase in the mechanical properties of the tissues.
- Publication
Nature biotechnology, 1999, Vol 17, Issue 10, p979
- ISSN
1087-0156
- Publication type
Journal Article
- DOI
10.1038/13671