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- Title
Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I.
- Authors
Kanzaki, M; Zhang, Y Q; Mashima, H; Li, L; Shibata, H; Kojima, I
- Abstract
Calcium plays a critical part in the regulation of cell growth, and growth factors stimulate calcium entry into cells through calcium-permeable channels. However, the molecular nature and regulation of calcium-permeable channels are still unclear at present. Here we report the molecular characterization of a calcium-permeable cation channel that is regulated by insulin-like growth factor-I (IGF-I). This channel, which we name growth-factor-regulated channel (GRC), belongs to the TRP-channel family and localizes mainly to intracellular pools under basal conditions. Upon stimulation of cells by IGF-I, GRC translocates to the plasma membrane. Thus, IGF-I augments calcium entry through GRC by regulating trafficking of the channel.
- Publication
Nature cell biology, 1999, Vol 1, Issue 3, p165
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/11086