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- Title
Noggin is a mesenchymally derived stimulator of hair-follicle induction.
- Authors
Botchkarev, V A; Botchkareva, N V; Roth, W; Nakamura, M; Chen, L H; Herzog, W; Lindner, G; McMahon, J A; Peters, C; Lauster, R; McMahon, A P; Paus, R
- Abstract
The induction of developmental structures derived from the ectoderm, such as the neural tube or tooth, occurs through neutralization of the inhibitory activity of members of the bone-morphogenetic protein (BMP) family by BMP antagonists. Here we show that, during hair-follicle development, the neural inducer and BMP-neutralizing protein Noggin is expressed in the follicular mesenchyme, that noggin-knockout mice show significant retardation of hair-follicle induction, and that Noggin neutralizes the inhibitory action of BMP-4 and stimulates hair-follicle induction in embryonic skin organ culture. As a crucial mesenchymal signal that stimulates hair-follicle induction, Noggin operates through antagonistic interactions with BMP-4, which result in upregulation of the transcription factor Lef-1 and the cell-adhesion molecule NCAM, as well as through BMP4-independent downregulation of the 75 kD neurotrophin receptor in the developing hair follicle.
- Publication
Nature cell biology, 1999, Vol 1, Issue 3, p158
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/11078