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- Title
Behavioral pharmacological similarities between methylphenidate and cocaine in cocaine abusers.
- Authors
Rush, C R; Baker, R W
- Abstract
Six human participants with recent histories of cocaine use were trained to discriminate 200 mg oral cocaine hydrochloride. A range of doses of oral cocaine (50-300 mg), methylphenidate (15-90 mg), triazolam (0.125-0.75 mg), and placebo were then tested to determine whether they shared discriminative-stimulus and participant-rated effects with 200 mg cocaine. Cocaine and methylphenidate dose-dependently increased cocaine-appropriate responding, produced prototypical stimulant-like participant-rated drug effects (e.g., increased participant ratings of Drug Liking), and increased heart rate and blood pressure. Triazolam produced low levels of cocaine-appropriate responding and impaired performance. Thus, consistent with previous studies, humans can reliably discriminate oral cocaine. Consistent with in vivo behavioral neuropharmacological data, the discriminative-stimulus, participant-rated, and physiological effects of oral cocaine and methylphenidate were similar.
- Publication
Experimental and clinical psychopharmacology, 2001, Vol 9, Issue 1, p59
- ISSN
1064-1297
- Publication type
Journal Article
- DOI
10.1037/1064-1297.9.1.59