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- Title
A comparison of anticonvulsants in the treatment of impulsive aggression.
- Authors
Stanford, Matthew S; Helfritz, Laura E; Conklin, Sarah M; Villemarette-Pittman, Nicole R; Greve, Kevin W; Adams, Donald; Houston, Rebecca J
- Abstract
This study compared the behavioral effects of 3 anticonvulsants in impulsive aggressive men. In a double-blind, placebo-controlled, parallel groups design, participants were randomly assigned to 1 of 4 6-week treatments: phenytoin (n = 7), carbamazepine (n = 7), valproate (n = 7), or placebo (n = 8). The efficacy measure was the average aggression score, a global severity index from the Overt Aggression Scale (J. M. Silver & S. C. Yudofsky, 1991). Analysis showed a significant reduction in impulsive aggression during all 3 anticonvulsant conditions compared with placebo. However, the treatment effect during carbamazepine administration was slightly delayed compared with phenytoin and valproate. These findings suggest that increased use of anticonvulsants could make a significant impact in the control of impulsive aggression in both mental health and criminal justice settings.
- Publication
Experimental and clinical psychopharmacology, 2005, Vol 13, Issue 1, p72
- ISSN
1064-1297
- Publication type
Journal Article
- DOI
10.1037/1064-1297.13.1.72