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- Title
Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner.
- Authors
Milad, M R; Vidal-Gonzalez, I; Quirk, G J
- Abstract
The authors recently showed that extinction of auditory fear conditioning leads to potentiation of tone-evoked activity of neurons in the infralimbic (IL) subregion of the medial prefrontal cortex, suggesting that IL inhibits fear after extinction (M. R. Milad, & G. J. Quirk, 2002). In support of this finding, pairing conditioned tones with brief (300-ms) electrical stimulation of IL reduces conditioned freezing. The present study showed that IL stimulation inhibits freezing if given 0.1 s after tone onset (the latency of tone-evoked responses) but has no effect if given either 1 s before or 1 s after tone onset. This suggests that IL gates the response of downstream structures such as the amygdala to fear stimuli.
- Publication
Behavioral neuroscience, 2004, Vol 118, Issue 2, p389
- ISSN
0735-7044
- Publication type
Journal Article
- DOI
10.1037/0735-7044.118.2.389