We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fluoxetine, smoking, and history of major depression: A randomized controlled trial.
- Authors
Spring, Bonnie; Doran, Neal; Pagoto, Sherry; McChargue, Dennis; Cook, Jessica Werth; Bailey, Katherine; Crayton, John; Hedeker, Donald
- Abstract
The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.
- Publication
Journal of consulting and clinical psychology, 2007, Vol 75, Issue 1, p85
- ISSN
0022-006X
- Publication type
Journal Article
- DOI
10.1037/0022-006X.75.1.85