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- Title
Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy.
- Authors
Constantini, Patricia K; Wawrzynowicz-Syczewska, Marta; Clare, Michael; Boron-Kaczmarska, Anna; McFarlane, Ian G; Cramp, Mathew E; Donaldson, Peter T
- Abstract
Though there is a consensus that the HLA DQB1*0301 allele is important in untreated HCV clearance, this association is not universal and a number of genes outside the major histocompatibility complex may also play a role in host responses to HCV infection. Prime candidates, at present, are the genes encoding pro-inflammatory and immuno-regulatory cytokines. The aim of this study was to investigate the relationship between a number of these candidate genes and both spontaneous and treatment related clearance of hepatitis C virus infection.
- Publication
Liver, 2002, Vol 22, Issue 5, p404
- ISSN
0106-9543
- Publication type
Journal Article
- DOI
10.1034/j.1600-0676.2002.01553.x