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- Title
Identification of a novel DRB1-allele (DRB1*0106) by sequence-based typing.
- Authors
Palou, E; Mongay, L; Arias, M T; Isart, F; Suárez, B; Massó, M; Fabregat, V; Martorell, J; Gayá, A
- Abstract
We report herein the identification of a new DRB1 allele using sequence-based typing. The new allele, DRB1*0106, was detected during routine HLA typing of a patient undergoing bone marrow transplantation. DRB1*0106 is identical to DRB1*0101 except for two codons, 71 (AGG-->GCG) and 86 (GGT-->GTG), changing the encoded arginine to alanine and glycine to valine. Both sequences were confirmed by polymerase chain reaction with sequence-specific primers (PCR-SSP). The polymorphism at codon 71 has not been, until now, identified in DRB1*01 alleles, although it is present in all the DRB1*15 alleles as well as DRB1*1309 and DRB1*1424.
- Publication
Tissue antigens, 1999, Vol 53, Issue 3, p308
- ISSN
0001-2815
- Publication type
Journal Article
- DOI
10.1034/j.1399-0039.1999.530313.x