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- Title
Exclusion of linkage to the HLA region in ninety multiplex sibships with autism.
- Authors
Rogers, T; Kalaydjieva, L; Hallmayer, J; Petersen, P B; Nicholas, P; Pingree, C; McMahon, W M; Spiker, D; Lotspeich, L; Kraemer, H; McCague, P; Dimiceli, S; Nouri, N; Peachy, T; Yang, J; Hinds, D; Risch, N; Myers, R M
- Abstract
Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the null expectation of 50% sharing of alleles in this region; in fact, for most marker loci, the observed sharing was less than 50%. Thus, it is unlikely that loci in this region contribute to the genetic etiology of autism to any significant extent in our families.
- Publication
Journal of autism and developmental disorders, 1999, Vol 29, Issue 3, p195
- ISSN
0162-3257
- Publication type
Journal Article
- DOI
10.1023/a:1023075904742